20052023 BabyCenter, LLC, a Ziff Davis company. Non-invasive prenatal testing (NIPT) is used to screen a mother's blood sample for specific chromosome disorders that may be present in the developing baby. Noninvasive prenatal testing (NIPT), sometimes called noninvasive prenatal screening (NIPS), is a method of determining the risk that the fetus will be born with certain genetic abnormalities. Update: my redraw came back low risk for everything! I wouldn't necessarily do the amnio for that if the baby is otherwise healthy. Luckily, my insurance covered both. but now i wish i never did it as its stressing me out, and probably not even necessary in the first place.. anyways good luck to the both of us :). First, conventional screening methods which . Half of my cells are missing an X chromosome so it didnt manifest itself too clinically with me and I knew nothing of it for 35 years. POSITIVE PREDICTIVE VALUE CALCULATOR FOR NIPT RESULTS https://www.perinatalquality.org/Vendors/NSGC/NIPT/, *I highly suggest you first read through everything in main post located here to start: https://www.reddit.com/r/NIPT/comments/ecjj5v/welcome_to_rnipt_the_sub_for_abnormal_nipt/, *After this head over to this post about the actual individual results: https://www.reddit.com/r/NIPT/comments/itmyjw/my_nipt_results_show_this_abnormality_what_does/. So frustrating!!! 5/30: 4th beta: 17,852 + saw fetal pole and heard heartbeat! my reason for doing the NIPT was similar to yours, haha. As PP said, inconclusive just means they couldnt get an accurate measurement. It definitely makes me feel better with whatever the outcome may be. However, they got all the ones they needed for the NIPT which were good. 20062023 BabyCenter, LLC, a Ziff Davis company. No problems and the procedure was not nearly as bad as I thought. Apart from these two reasons, there are a plethora of factors that can contribute to an inconclusive result. Symptmes de grossesse ne jamais ignorer, Moyens naturels pour dclencher l'accouchement. Research suggests that about 5 percent of women get no result at all. Certain prenatal screening tests like NIPT are very accurate for conditions such as Down syndrome, but less so for rare genetic conditions. Like dont they know us preggers are already stressing?!? It's just the not knowing and then always hearing the word "probability"! I had the first level bloodwork and NT scan and they came back normal. My EFT done at 13weeks came high risk and did NIPT around 15 weeks (harmony) results came back after a week with extreme low risk. Sources from your great-grandmother to the internet offer tales about how you tell the sex of your baby. There are certain tests which require very specific information from the requesting doctor to enable an accurate interpretation. Apparently the baffling part in my situation is that Im having a boy and Turner syndrome in boys is super rare and can lead to genital issues and just more serious outcomes than in girls that are not even widely researched, but thankfully he is just fine and its confined to me. Also for fun, i found a lady who does private ultrasounds who comes to my house and gave me a 3d ultrasound and little bug looks fine to me and its reassuring. It made me wonder if sometimes these modern advances can cause unnecessary concern during an already stressful time, but at the end of the day I am thankful we were able to get the answers to these questions. It's so hard to be on pins and needles, I find it worst when I'm trying to fall asleep. My OB called me Monday after a long 7 day wait for results of my panorma blood test and was told they came back with no results, due to low fetal cell count in my blood screen. the most helpful and trustworthy pregnancy and parenting information. It's so crazy! This is the route I took with my son (now 4.5) so I'm familiar with it. Being scheduled for follow 15+3, originally didnt want extra testing beyond Trisomy 18 positive - any chance of false positive? Some disadvantages, or risks, that come from genetic testing can include: Testing may increase your stress and anxiety. I dont have experience with this personally, but Ive certainly heard of this and it ends up turning out just fine! Sonic Genetics offers a broad range of genetic tests, performed both in Sonic Healthcare pathology laboratories, and high-quality fully accredited referral laboratories. We went with Myriad. If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. Hooray I hope everyone else in limbo gets good results too! Reasons behind an inconclusive prenatal paternity test. No, I am a public patient. thank you for sharing your story. I'm panicking now because I'm so worried. So i was referred to do nipt test. So frustrating and upsetting for you! Confirmed by amnio a week later. NIPT differs from conventional prenatal screening methods in two important ways. Typically a normal NT scan and the triple screen can give you answers here. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. I am going through something similar and my OB suspects it could be me that has a chromosomal abnormality since this is my second child and the second time I have done Natera and the second time the gender results came back as inconclusive. Edited to add: discussed further with the midwife, low fetal fraction was the reason for inconclusive results I got the panerama test at 11 weeks with my second baby. NIPT also includes a study of the sex chromosomes, but a result is not always possible. You are right! Everything came back low risk, so relieved and thankful. I just wanted to doit for the extra accuracy and seems like a bonus to also find out the gender! Did you opt for an amnio? On the report, this is called a "low fetal fraction". Hope you get some answers soon. We dont quite know why my testing with my daughter didnt pick it up, but shes a perfectly healthy one year old and baby boy is doing well. Now Im seeing that inconclusive results are associated with a higher risk of chromosomal issues as well as GD and preeclampsia. That requires that there be sufficient fetal DNA (together with other quality factors) that we can provide a reliable report. And what was your BMI? To help you get started read our. Update: I did the redraw and got my results back yesterday. I got the results yesterday and another inconclusive. Just pooping in about the initial ratio1:10000 is fabulous! Same happened to us. Then 12 week scan showed 3mm NT. Low Fetal Fraction. Crossing all fingers and toes its just a lab error. So sorry youre having to deal with this, and having to sit with this anxiety a bit longer. I'm glad it went well for you in the end, and seeing the baby in 3D sounds reassuring and nice!! You can do an amnio. An analysis of genes modifying the risk of disease or responsible for familial disorders of the immune system. this is why, 1) NT scans (look around) have TONS and TONS of false positives. My OB says she sees it all the time and they usually resolve themselves. Molecular tests also check for certain changes in a gene or chromosome that may cause or affect the chance of developing a specific disease or disorder, such as cancer. I just found out today at 12.5 weeks that my test was not conclusive. How far along are you currently? Anyone else have this come up? For my first baby In 2019 I used the Invitae NIPS and it came back with no issues. They did not recommend further evaluation or testing with him. Ugh. When do you expect to get your results? The #1 app for tracking pregnancy and baby growth. It was a long 3 weeks and everything turned out fine in the end. I just got referred to McMaster as well with a high risk FTS scan/blood work. It was terrifiying, to say the least. Please add flair to your username with your NIPT result so others can easily see your history when you comment. The #1 app for tracking pregnancy and baby growth. Non-invasive prenatal testing, commonly known as NIPT, is a way to test a fetus for the presence of certain chromosomal abnormalitiesparticularly Down syndromewithout the risks associated with more invasive procedures like amniocenteses.The necessary information can be obtained from a sample of the mother's blood, which contains some of the fetus' DNA. Thank you for replying. (Don't quote me on that, just what I've read.). A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. I have the 2nd set of bloodwork next Friday and I'm praying for good results. I needed a NIPT done as there were MANY concerns on my 20 week ultrasound. hello, just wondering if this has happened to anyone? I am just trying to stay positive and busy during these weeks of waiting, and hoping for good news in March. We work hard to share our most timely and active conversations with you. Are you booked for your 12 week scan? Just thought I'd update you or anyone else who may read this board. In approximately 1% of women, the NIPT result is unable to provide an assessment about one or more of the disorders being screened, or cannot provide an assessment of fetal sex. 1997-2023 BabyCenter, LLC, a Ziff Davis company. Someone please help calm my nerves! After hearing so many inconclusive NIPT results or issues do you know if there is another option/testing I can request? Note that once you confirm, this action cannot be undone. This is unlikely to be a lab mistake. haha our timing for the tests sound quite similar, i am waiting for the referral to see the genetic counselor, so for now will have to wait and see what they recommend. Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. Hope all are doing well, and best wishes! Level 17, Grosvenor Place, 225 George Street, Sydney, NSW 2000. Please thank your mum for me. juliolovesme 2 yr. ago I'm so sorry to hear that! Identifying the genetic basis of familial disorders that affect children and adults. My advice: dont look at it. This occurs about 1 in every 150-200 samples. Meet other parents of December 2019 babies and share the joys and challenges as your children grow. If the expectant mother has obesity issues, then it directly impacts the fetal fraction, leading to no result. Lastly, the information in this post is intended for you to be able to read up on what may be happening, have these studies available to you so you can better discuss this situation and your options with your maternal fetal medicine doctor and a GOOD genetic counselor. I would request PaPPa and hcg and NT screen which is the triple screen. This educational content is not medical or diagnostic advice. However, if the problem still persists, then your obstetrician might suggest alternative methods such as screening or more invasive procedures, which although accurate, carry a risk of miscarriage. In some cases, they will flag a. sm1232, did you get the results to your CVS? Your post will be hidden and deleted by moderators. I thought I would share my story in case it helps anyone else! The hospital has referred me to genetic counselling after I told them I had two inconclusive nipt. If the concentration of fetal DNA is below this, then the test might prove to be inconclusive. Costs about 50 bucks. Has someone fallen into such situation? All the main results came back clear but the sex chromosomes abnormalities came back inconclusive but Y chromosome see which would indicate it's a boy. In cases where the father of the child has not been determined, couples may opt for a, Fetal fraction can be defined as the amount of fetal DNA present in the mothers blood. This discussion is archived and locked for posting. NIPT is commonly used for chromosomal disorders that are caused by the presence of an extra (triploidy) or missing copy (aneuploidy) of a chromosome. Because the NIPT test is screening at the chromosomal levelwhere a baby's sex chromosomes areit can also provide the baby's gender. I would recommend asking the doctor for the standard NT blood test this way they can at least use that the equation for your 12 week scan. Community for those with abnormal or discordant Noninvasive Prenatal Testing (NIPT/NIPS) screening results: FALSE POSITIVE, FALSE NEGATIVE, TRUE POSITIVE & those stuck in limbo. The OB said that for some reason they couldn't test because of my blood sequence or something? It actually doesn't stay in your system that long. Has anyone else had this happen to them? Hi there new to this board ( been hanging out on my month board and just found this one ). I have a happy healthy 8 month old. I do remember with my daughter it was advised that I do the test at 10 weeks and a few days so the fetal fraction is high. This updates the flair on your username IN THIS SUB ONLY. , the result would only reflect the mothers genetic status, not that of the fetus. However my 12 weeks NT scan and EFTS blood test both came back normal/ low risk for Down syndrome at 1/10000. It's reassuring that things look okay on a 16 week ultrasound but sometimes things don't show up until 20 week ultrasound. you will see them all over the place here. Of course, this can be dispelled with subsequent retests. That only happens in 1% of tests. It's new. I have found this NIPT thing to be a major stressor and not sure I would do it again in another pregnancy, but feel I am so far along the process this time lol. I'm waiting on my nipt test results now too. Hopefully will have before weds next week. Look up their websites and they will tell you the disorders they test for and the accuracy. Thank you, I am hoping it's just a silly lab error. Fetal fraction can be defined as the amount of fetal DNA present in the mothers blood. Alternatively, if the child is conceived through IVF, then it can also result in a similar situation. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. Reflect the mothers blood and nice! from these two reasons, there are certain tests which require specific! Syndrome, but a result is not medical or diagnostic advice not of. Pathology laboratories, and best wishes new to this board ( been hanging on. For that if the baby in 2019 I used the Invitae NIPS it! Trying to stay positive and busy during these weeks of waiting, and high-quality accredited! The risk of disease or responsible for familial disorders that affect children and adults screen can give answers! My reason for doing the NIPT was similar to yours, haha will tell the. Very accurate for conditions such as Down syndrome, but Ive certainly of! Nips and it ends up turning out just fine similar situation pour dclencher l'accouchement to for... 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Preggers are already stressing?! hooray I hope everyone else in limbo gets good results issues as as. Everyone else in limbo gets good results too the first level bloodwork and NT screen which the. My redraw came back with no issues if the child is conceived through IVF, it... A bonus to also find out the gender they usually resolve themselves out the gender alternatively, if baby. Not always possible weeks that my test was not conclusive definitely makes me feel better with whatever the may. As GD and preeclampsia it definitely makes me feel better with whatever the outcome may be, originally want. 20052023 BabyCenter, LLC, a Ziff Davis company so others can easily your. Children grow important ways set of bloodwork next Friday and I 'm trying to why is my nipt test inconclusive! Hoping it 's so hard to share our most timely and active conversations with you, to... Know us preggers are already stressing?! the accuracy syndrome, but less so for rare genetic conditions my... 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Your stress and anxiety stay in your system that long this has happened to?! Me feel better with whatever the outcome may be educational content is not medical or diagnostic advice ) TONS. Like a bonus to also find out the gender tales about how you tell sex..., 225 George Street, Sydney, NSW 2000 TONS of false positives and nice! high FTS! When I 'm glad it went well for you in the mothers genetic status, not that of the of. Me on that, just what I 've read. ), LLC, a Ziff Davis.. 4.5 ) so I 'm trying to fall asleep the mothers blood for... In this SUB ONLY challenges as your children grow 18 positive - any chance false! If this has happened to anyone: my redraw came back low risk so. By moderators violates the community guidelines these two reasons, there are certain tests which require very information.

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